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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Yungan Tao, ESMO 2018 – Developments in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinomas

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Published Online: Nov 2nd 2018

In this interview at ESMO 2018, Dr Yungan Tao speaks about the GORTEC 2004-01 randomised phase III trial which looked at 70 Gy/35 F with conventional radiotherapy versus 75 Gy/35 F with intensity-modulated radiotherapy. Dr Tao explains the results and limitations of the study and how this information adds to the body of evidence to support the use of intensity-modulated radiotherapy for locally advanced head and neck squamous cell carcinomas.

Questions:
1. What is intensity-modulated radiotherapy (IMRT) and what are its advantages compared with conventional radiotherapy? (0:11)
2. What was the rationale for investigating dose escalation of radiotherapy when administered with cisplatin? (0:46)
3. What were the findings of this study? (1:26)
4. What were the limitations of this study? (2:53)
5. How do you expect the role of IMRT to evolve in the future? (3:43)

Speaker disclosures: Yungan Tao has nothing to disclose in relation to this interview.

Filmed at the European Society for Medical Oncology (ESMO) 2018 Congress, Munich, Germany, 19–23 October 2018.

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