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Esophageal cancer (EC) is a major global health concern, ranking as the 11th most commonly diagnosed cancer and the seventh leading cause of cancer-related deaths worldwide, with an estimated 494,320 new cases and 441,994 deaths in 2024.1 Esophageal squamous cell carcinoma (ESCC) remains the predominant subtype globally (84% of new cases), while esophageal adenocarcinoma (EAC) […]

Bernd Jilma, ASH 2022: The pathophysiology and unmet treatment needs in cold agglutinin disease

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Published Online: Jan 11th 2023

Cold agglutinin disease (CAD) is a rare, autoimmune, clonal B cell disorder. In this touchONCOLOGY interview, we speak with Dr Bernd Jilma (Medical University of Vienna, Vienna, Austria) to discuss the pathophysiology of CAD and the unmet treatment needs in this disease.

The abstract entitled ‘Trial in Progress: Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with Cold Agglutinin Disease (CASCADE)’ (Abstract #2333)  was presented at ASH Annual Meeting, 10–13, December, 2022.

Question:

Could you tell us a little about cold agglutinin disease (CAD), its pathophysiology and the unmet needs in its treatment? (0:17)

Disclosures: Bernd Jilma is on the advisory board, speaker’s bureau and a consultant for Sanofi as well as having received grant/research support and honoraria from Sanofi. 

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ASH 2022

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