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Trifluridine/Tipiracil and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

touchREVIEWS in Oncology & Haematology. 2024;20(2):Online ahead of journal publication

Trifluridine/Tipiracil and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

touchREVIEWS in Oncology & Haematology. 2024;20(2):Online ahead of journal publication

Gynaecological Cancers

2 mins

Keiichi Fujiwara, ESMO 2022: Clinical trial highlights in gynaecological cancer

Published Online: Sep 12th 2022

Dr Keiichi Fujiwara joins touchONCOLOGY to discuss his thoughts on the latest clinical trial highlights at European Society for Medical Oncology (ESMO) 2022 in gynaecological cancers, specifically the GOTIC-002 LUFT study.

Watch Dr Keiichi Fujiwara’s interview at ESMO 2022, on the Phase 3 GOTIC-002 LUFT study results – chemotherapy with tegafur-uracil for locally advanced cervical cancer

Questions:

What are the hot topics and clinical trial highlights in gynaecological cancer from ESMO?

Disclosures: Keiichi Fujiwara receives grant/research support from Taiho; is on the advisory board for Daiichi Sankyo, Seagen, and Genmab; and receives honoraria/honorarium from Kiowa KIRIN.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.

Filmed in coverage of ESMO 2022

Access more gynaecological oncology here

Niraparib as first-line maintenance treatment in ovarian cancer

Antonio González Martín

The phase III PRIMA/ENGOT-OV26/GOG-3012 trial evaluated the efficacy of niraparib as a first-line maintenance treatment for patients with advanced ovarian cancer who responded to platinum-based chemotherapy. In this final analysis, no significant difference in overall survival was observed between niraparib and placebo in the overall or homologous recombination-deficient (HRd) populations. However, long-term progression-free survival and […]

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Bradley J Monk

The ATHENA trial evaluated the effectiveness of rucaparib (RUCA) monotherapy (MONO) and rucaparib combined with nivolumab (NIVO) (COMBO) in patients with advanced high-grade ovarian cancer (AHGOC). In the MONO arm, rucaparib showed sustained progression-free survival (PFS) of 20.2 months after first-line ...

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The annual European Society of Gynaecological Oncology (ESGO) Congress, held from 7–10 March 2024, in Barcelona, Spain, celebrated its 25th anniversary this year. This year’s congress brought together over 2,500 participants from all over the world, and featured groundbreaking research, clinical advancements and professional development opportunities.

Key insights in gynecological malignancies: BrUOG 354, AGO-OVAR 2.29/ENGOT-ov34, KEYVIBE-005, CARACO

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To further understand the key developments and research presented in the field of gynaecological oncology at ASCO 2024, we spoke with Dr. Domenica Lorusso, Professor of Obstetrics and Gynaecology at Humanitas University of Milan, Italy. In this interview, Dr. Lorusso discusses the findings from the BrUOG 354 (NCT03355976), AGO-OVAR 2.29/ENGOT-ov34 (NCT03353831), KEYVIBE-005 (NCT05007106), and CARACO (NCT01218490) trials, offering her valuable insights into the potential impact these results could have on clinical practice.

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Highlights in gynaecological oncology: Domenica Lorusso, ESMO 2023

To further understand the key developments and research presented in the field of gynaecological oncology at ESMO 2023, we spoke with Dr Domenica Lorusso, Professor of Obstetrics and Gynaecology at the Fondazione Policlinico Universitario Agostino Gemelli - UCSC Italy. In our ...

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Navigating HRT and cancer risk: PrEvCan | Celia Diez de los Rios

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The Phase III SOLO1/GOG-3004 trial (NCT01844986), investigated maintenance olaparib, which provided sustained benefit beyond the end of treatment in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation. Prof. Paul DiSilvestro (Brown University, Providence, RI, USA) joins ...

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Keiichi Fujiwara, ESMO 2022: Phase 3 GOTIC-002 LUFT study results - Chemotherapy with tegafur-uracil for locally advanced cervical cancer

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Trifluridine/Tipiracil and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Conference Coverage

Learning Activities

Journals

Trifluridine/Tipiracil and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Keiichi Fujiwara, ESMO 2022: Clinical trial highlights in gynaecological cancer

Niraparib as first-line maintenance treatment in ovarian cancer

Addition of nivolumab to rucaparib did not improve clinical outcomes in newly diagnosed, advanced, high-grade ovarian cancer

ESGO 24: Advances in cervical, endometrial and ovarian cancer

Key insights in gynecological malignancies: BrUOG 354, AGO-OVAR 2.29/ENGOT-ov34, KEYVIBE-005, CARACO

Highlights in gynaecological oncology: Domenica Lorusso, ESMO 2023

Navigating HRT and cancer risk: PrEvCan | Celia Diez de los Rios

Cancer prevention and the power of breastfeeding: PrEvCan | Celia Diez de los Rios

Paul DiSilvestro, ESMO 2022: SOLO1/GOG-3004 trial - Olaparib for the treatment of advanced ovarian cancer - Overall survival findings at 7 years

Keiichi Fujiwara, ESMO 2022: Phase 3 GOTIC-002 LUFT study results - Chemotherapy with tegafur-uracil for locally advanced cervical cancer

Domenica Lorusso, ASCO 2022: Trabectedin for the treatment of recurrent ovarian, primary peritoneal, or fallopian tube cancers - Phase 3 MITO23 trial results

Ruth Perets, AACR 2022: Vibostolimab / Pembrolizumab Coformulation for the Treatment of Ovarian Cancer Naive to PD-1/PD-L1 Inhibitors

Domenica Lorusso, ESMO 2021: Relacorilant in Combination with Nab-paclitaxel for Patients with Recurrent Platinum-resistant Ovarian Cancer

Julius Strauss, ESMO 2021: Long-term Follow-up of Patients with HPV–associated Malignancies Treated with Bintrafusp Alfa

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