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Arlene Siefker-Radtke, ESMO 2019 – KEYNOTE-866 Phase III trial in bladder cancer

Published Online: October 7th 2019

We are joined by Arlene Sietker-Radtke (The University of Texas MD Anderson Cancer Center) at ESMO 2019 to discuss her presentation on the results from the KEYNOTE-866 trial (NCT03924856). This phase III study investigates perioperative pembrolizumab or placebo in combination with neoadjuvant chemotherapy in cisplatin-eligible patients with muscle-invasive bladder cancer.

Questions

What are the limitations of the current treatment of muscle-invasive bladder cancer with neoadjuvant chemotherapy? (0:04)
What is the rationale for using pembrolizumab in the perioperative treatment setting? (0:37)
Could you tell us about the aims and design of the KEYNOTE-866 study? (1:23)
What are the eligibility criteria for this study? (1:58)
What are the most promising emerging biomarkers for response to pembrolizumab in bladder cancer? (2:28)

 

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

Speaker disclosure: Arlene Siefker-Radtke has participated in advisory boards for Merck.

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