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This issue of touchREVIEWS in Oncology & Haematology brings together a diverse collection of articles reflecting the growing complexity of cancer care and the continued evolution of precision medicine across tumour types. From rare malignancies and treatment-related challenges to emerging targeted therapies and novel biological insights, the contributions highlight both recent progress and the significant […]

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High-Risk HR+, HER2− Early Breast Cancer: Risk Stratification, Adjuvant CDK4/6 Inhibitors, and Long-Term Outcomes

Topics Covered:
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HR+ HER2- Early Breast Cancer Education: Unmet need and patient identification

HR+ HER2- early breast cancer Education: Overall survival in the Adjuvant setting

High Risk HR+ HER2 Early Breast Cancer: CDK4/6 Inhibitor Trials

HR+ HER2 Early Breast Cancer Education: Adherence and AE management

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Expert videos in HR+, HER2− EBC

Unmet Need and Patient Identification

Stephen Johnston & Shaheenah Dawood
Duration: 5:11

Achieving Overall Survival in the Adjuvant Setting

Stephen Johnston
Duration: 3:07

CDK4/6 Inhibitor Trials

Stephen Johnston
Duration: 10:47

Adherence and AE Management

Stephen Johnston & Shaheenah Dawood
Duration: 5:13

Activity Overview

Faculty & Disclosures

Activity Overview
Faculty & Disclosures

This activity brings together expert-led video discussions focused on the identification and management of patients with high-risk HR+, HER2− early breast cancer (EBC).

Across four videos, faculty explore the unmet need in patients with node-positive high-risk disease, including those with 1–3 positive lymph nodes and additional high-risk clinicopathological features, review the monarchE and NATALEE trial designs and outcomes, and discuss practical strategies for adverse event management and treatment persistence with adjuvant CDK4/6 inhibitors.

Supporting infographics reinforce key concepts around recurrence risk, patient selection, trial interpretation, and dose modification strategies, while links throughout the activity direct learners to the accompanying interactive patient case simulation and infographic resources for further exploration.

  • Evaluate lymph node involvement and additional high-risk features in patients with 1–3 positive lymph nodes to assess risk of disease recurrence and guide treatment strategies
  • Assess which patients may benefit from the addition of a CDK4/6 inhibitor and formulate individualized treatment plans to optimize treatment selection
  • Formulate strategies to anticipate and manage adverse events associated with CDK4/6 inhibitors to support treatment adherence and maximize clinical outcomes

Prof. Stephen Johnston

The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London
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Prof. Stephen Johnston

The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London
UK

Disclosures

Dr Shaheenah Dawood

Mediclinic City Hospital, Dubai

Dr Shaheenah Dawood

Mediclinic City Hospital, Dubai
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Dr Shaheenah Dawood

Mediclinic City Hospital, Dubai
United Arab Emirates

Disclosures

Prof. Stephen Johnston

The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London

Video Navigation

Expert videos in HR+, HER2− EBC

Unmet Need and Patient Identification

Stephen Johnston & Shaheenah Dawood
Duration: 5:11

Achieving Overall Survival in the Adjuvant Setting

Stephen Johnston
Duration: 3:07

CDK4/6 Inhibitor Trials

Stephen Johnston
Duration: 10:47

Adherence and AE Management

Stephen Johnston & Shaheenah Dawood
Duration: 5:13

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This activity has been funded by Eli Lilly and Company Ltd.

Eli Lilly and Company Ltd. provided financial support and video content, and has had input into the detailed project scope. This activity is provided by touchMEDICAL for touchONCOLOGY.

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Eli Lilly and Company Ltd. provided financial support and content, and has had input into the detailed project scope. This activity is provided by touchMEDICAL for touchONCOLOGY.

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