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How do you clearly discuss recurrence risk with patients?
Prof Stephen Johnston and Dr Shaheenah Dawood explore risk factors, real‑world data, and practical approaches to communicating recurrence risk in HR+ HER2‑ early breast cancer.
MMAT‑03206; MMAT-04313; MMAT-04605; CMAT-33776; MMAT-05254; TO28052026; VV-MED-183254; CMAT-38790
How has overall survival evolved in HR+ HER2‑ early breast cancer trials?
Prof Stephen Johnston reviews two decades of adjuvant trial data, exploring what the evidence shows and where challenges remain.
MMAT‑03207; MMAT-04312; MMAT-05188; CMAT-33931; MMAT-05252; TO28052026; VV-MED-183253; CMAT-38788
Prof Stephen Johnston provides a concise overview of the latest efficacy and safety data from CDK4/6 inhibitor trials, including trial design, primary outcomes, and dose modifications.
An overall survival (OS) benefit that was statistically significant was observed in the ITT population. Following consultation with regulatory authorities at the primary IDFS analysis, the OS analysis plan was modified to increase the number of final events from 390 to 650 in order to ensure a follow-up of at least 5 years. Abemciclib is approved for Cohort 1 (91% of the ITT population); the OS analysis in this subpopulation was not powered for statistical significance or alpha error control.
MMAT-03306; MMAT-04428; MMAT-04606; CMAT-33774; MMAT-05251; TO28052026; VV-MED-183249; CMAT-37933
Adherence and toxicity can limit the impact of effective therapies.
In this video, Dr Shaheenah Dawood and Prof Stephen Johnston examine real‑world challenges in high-risk HR+ HER2‑ early breast cancer, from treatment adherence and patient communication to dose optimisation and adverse‑event management.
MMAT-03305; MMAT-04314; MMAT-04571; CMAT-33935; MMAT-05255; TO28052026; VV-MED-183255; CMAT-38792
This activity brings together expert-led video discussions focused on the identification and management of patients with high-risk HR+, HER2− early breast cancer (EBC).
Across four videos, faculty explore the unmet need in patients with node-positive high-risk disease, including those with 1–3 positive lymph nodes and additional high-risk clinicopathological features, review the monarchE and NATALEE trial designs and outcomes, and discuss practical strategies for adverse event management and treatment persistence with adjuvant CDK4/6 inhibitors.
Supporting infographics reinforce key concepts around recurrence risk, patient selection, trial interpretation, and dose modification strategies, while links throughout the activity direct learners to the accompanying interactive patient case simulation and infographic resources for further exploration.
After watching this activity, participants should be better able to:
Consulting/advisory board for AstraZeneca, Eli Lilly and Company, Novartis, Pfizer, and Roche-Genentech. Honoraria from AstraZeneca, Eli Lilly and Company, Novartis, Pfizer, and Roche-Genentech. Grant/research funding from AstraZeneca, Eli Lilly and Company, and Pfizer. Expert testimony for Novartis.
Honoraria from AstraZeneca, Biologics, BMS, Eli Lilly and Company, Novartis, Pfizer, and Roche-Genentech. Grant/research funding from Jalila Foundation and MSD.
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This activity has been funded by Eli Lilly and Company Ltd.
Eli Lilly and Company Ltd. provided financial support and content, and has had input into the detailed project scope. This activity is provided by touchMEDICAL for touchONCOLOGY.
Brazil, Canada, Germany, Greece, Kuwait, Portugal, Qatar, Spain, and United Arab Emirates.
Brazil, Canada, Germany, Greece, Kuwait, Portugal, Qatar, Spain, and United Arab Emirates.
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This activity has been funded by Eli Lilly and Company Ltd.
Eli Lilly and Company Ltd. provided financial support and video content, and has had input into the detailed project scope. This activity is provided by touchMEDICAL for touchONCOLOGY.
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Eli Lilly and Company Ltd. provided financial support and content, and has had input into the detailed project scope. This activity is provided by touchMEDICAL for touchONCOLOGY.
No endorsement by Eli Lilly or touchMEDICAL of any unapproved products or unapproved uses is either made or implied by mention of these products or uses in touchMEDICAL activities. touchMEDICAL accepts no responsibility for errors or omissions.
MMAT-05418; MMAT-06323; MMAT-06405; CMAT-40602; MMAT-07072; TO1072026; CMAT-42219
July 2026
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Canada: Eli Lilly Canada Inc. PrVERZENIOÒ Product Monograph. July 24, 2025
Spain: An overall survival (OS) benefit that was statistically significant was observed in the ITT population. Following consultation with regulatory authorities at the primary IDFS analysis, the OS analysis plan was modified to increase the number of final events from 390 to 650 in order to ensure a follow-up of at least 5 years. Verzenios® is approved for Cohort 1 (91% of the ITT population); the OS analysis in this subpopulation was not powered for statistical significance or alpha error control.
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