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3d illustration of human body liver
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Allan A Lima Pereira, Gabriel Lenz, Tiago Biachi de Castria

Despite being considered a rare type of malignancy, constituting only 3% of all gastrointestinal cancers, the incidence of biliary tract cancers (BTCs) has been increasing worldwide in recent years, with about 20,000 new cases annually only in the USA.1–3 These cancers arise from the biliary epithelium of the small ducts in the periphery of the liver […]

Gloria Huang, ASCO 2019 – NRG Oncology/Gynecologic Oncology Group 210 trial

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Published Online: Jun 10th 2019

Gloria Huang discusses results from the NRG Oncology/Gynecologic Oncology Group 210 trial at the ASCO 2019 annual meeting. The trial investigates sex hormone, insulin and insulin-like growth factor signaling in the recurrence of high stage endometrial cancer.

Questions

1. What is known about the role of sex hormone, insulin and insulin-like growth factor (IGF) axis signalling pathways in the development of endometrial cancer? (0:03)
2. What evidence exists for the use of metformin as a treatment for endometrial cancer? (0:44)
3. What other methods of targeting sex hormone, insulin and IGF axis signalling pathways appear promising? (1:27)
4. What were the findings of your study investigating these pathways in the recurrence of high-stage endometrial cancer? (2:41)
5. What are the clinical implications of these findings? (3:33)

Speaker disclosure: Gloria Huang has nothing to disclose in relation to this video interview.

Filmed at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Chicago, IL, USA.

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