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A Comprehensive Review of the Growing Landscape of Endocrine and Biologic Treatments for Hormone Receptor-positive Breast Cancer

Diana Zhang, Amira Ishag-Osman, Chiara Corti

Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

touchREVIEWS in Oncology & Haematology. 2024;20(2):Online ahead of journal publication

Gynaecological Cancers

2 mins

Keiichi Fujiwara, ESMO 2022: Clinical trial highlights in gynaecological cancer

Published Online: Sep 12th 2022

Dr Keiichi Fujiwara joins touchONCOLOGY to discuss his thoughts on the latest clinical trial highlights at European Society for Medical Oncology (ESMO) 2022 in gynaecological cancers, specifically the GOTIC-002 LUFT study.

Watch Dr Keiichi Fujiwara’s interview at ESMO 2022, on the Phase 3 GOTIC-002 LUFT study results – chemotherapy with tegafur-uracil for locally advanced cervical cancer

Questions:

What are the hot topics and clinical trial highlights in gynaecological cancer from ESMO?

Disclosures: Keiichi Fujiwara receives grant/research support from Taiho; is on the advisory board for Daiichi Sankyo, Seagen, and Genmab; and receives honoraria/honorarium from Kiowa KIRIN.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.

Filmed in coverage of ESMO 2022

Access more gynaecological oncology here

ESGO 24: Advances in cervical, endometrial and ovarian cancer

Jalid Sehouli

The annual European Society of Gynaecological Oncology (ESGO) Congress, held from 7–10 March 2024, in Barcelona, Spain, celebrated its 25th anniversary this year. This year’s congress brought together over 2,500 participants from all over the world, and featured groundbreaking research, clinical advancements and professional development opportunities.

Related Videos in Gynaecological Cancers

Key insights in gynecological malignancies: BrUOG 354, AGO-OVAR 2.29/ENGOT-ov34, KEYVIBE-005, CARACO

Domenica Lorusso

To further understand the key developments and research presented in the field of gynaecological oncology at ASCO 2024, we spoke with Dr. Domenica Lorusso, Professor of Obstetrics and Gynaecology at Humanitas University of Milan, Italy. In this interview, Dr. Lorusso discusses the findings from the BrUOG 354 (NCT03355976), AGO-OVAR 2.29/ENGOT-ov34 (NCT03353831), KEYVIBE-005 (NCT05007106), and CARACO (NCT01218490) trials, offering her valuable insights into the potential impact these results could have on clinical practice.

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Highlights in gynaecological oncology: Domenica Lorusso, ESMO 2023

To further understand the key developments and research presented in the field of gynaecological oncology at ESMO 2023, we spoke with Dr Domenica Lorusso, Professor of Obstetrics and Gynaecology at the Fondazione Policlinico Universitario Agostino Gemelli - UCSC Italy. In our ...

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Navigating HRT and cancer risk: PrEvCan | Celia Diez de los Rios

This July, the PrEvCan campaign is dedicated to raising awareness about women's cancer risk in connection with breastfeeding and hormone replacement therapy (HRT). Initiated by the European Oncology Nursing Society (EONS), and with ESMO as a key campaign partner, the ...

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Cancer prevention and the power of breastfeeding: PrEvCan | Celia Diez de los Rios

The relationship between breastfeeding and a reduction in cancer risk is the focus of the PrEvCan Campaign, this July. Initiated by the European Oncology Nursing Society (EONS), and with ESMO as a key campaign partner, the PrEvCan – Cancer Prevention Across ...

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Paul DiSilvestro, ESMO 2022: SOLO1/GOG-3004 trial - Olaparib for the treatment of advanced ovarian cancer - Overall survival findings at 7 years

The Phase III SOLO1/GOG-3004 trial (NCT01844986), investigated maintenance olaparib, which provided sustained benefit beyond the end of treatment in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation. Prof. Paul DiSilvestro (Brown University, Providence, RI, USA) joins ...

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Keiichi Fujiwara, ESMO 2022: Phase 3 GOTIC-002 LUFT study results - Chemotherapy with tegafur-uracil for locally advanced cervical cancer

Maintenance chemotherapy with oral tegafur-uracil (UFT) after surgery has been shown to prolong survival in lung, breast, gastric and colon cancer. Dr Keiichi Fujiwara (Saitama Medical University International Medical Centre, Saitama, Japan) joins touchONCOLOGY to discuss the phase 3 GOTIC-002 LUFT ...

Domenica Lorusso, ASCO 2022: Trabectedin for the treatment of recurrent ovarian, primary peritoneal, or fallopian tube cancers - Phase 3 MITO23 trial results

The phase 3 MITO23 trial investigated trabectedin (ET-743) single agent versus clinician’s choice chemotherapy in recurrent ovarian, primary peritoneal, or fallopian tube cancers of BRCA-mutated or BRCAness phenotype patients Dr Domenica Lorusso (Fondazione IRCCS National Cancer institute of Milan, Milan, ...

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Ruth Perets, AACR 2022: Vibostolimab / Pembrolizumab Coformulation for the Treatment of Ovarian Cancer Naive to PD-1/PD-L1 Inhibitors

We were delighted to speak with Dr. Ruth Perets (Rambam Health Care Campus, Haifa, Israel) about the efficacy and safety findings of the phase 1 study comparing vibostolimab (vibo) plus pembrolizumab (pembro) given sequentially to the coformulation of vibo/pembro in ...

Domenica Lorusso, ESMO 2021: Relacorilant in Combination with Nab-paclitaxel for Patients with Recurrent Platinum-resistant Ovarian Cancer

touchONCOLOGY joins Dr Domenica Lorusso (Rome, Italy), to discuss the improvements in progression-free survival in patients with recurrent platinum-resistant ovarian cancer using relacorilant in combination with nab-paclitaxel. (NCT03776812) Question Please summarise the randomized, open-label, phase II study presented at ESMO 2021 ...

Julius Strauss, ESMO 2021: Long-term Follow-up of Patients with HPV–associated Malignancies Treated with Bintrafusp Alfa

touchONCOLOGY joins Dr Julius Strauss (National Cancer Institute, National Institutes of Health, Bethesda, MD, USA), to discuss the long-term follow-up of patients with human papillomavirus–associated malignancies treated with bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1. Questions 1. ...

Shibani Nicum, ESMO 2021: First Results of the OCTOVA Trial

touchONCOLOGY joins Dr Shibani Nicum (University College London, UK) at ESMO 2021 to present the first results of the OCTOVA trial of olaparib compared to weekly paclitaxel or olaparib plus cediranib in patients with platinum-resistant ovarian cancer. Questions 1. What are the ...

Linda Mileshkin, ESMO 2019 - Phase III OUTBACK trial in cervical cancer

We joined Linda Mileshkin (Peter MacCallum Cancer Centre) following her presentation at ESMO 2019 to discuss the disparities of starting adjuvant chemotherapy for locally advanced cervix cancer in the international, academic, randomised, phase III OUTBACK trial. Questions 1. Could you tell us ...

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Conference Coverage

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A Comprehensive Review of the Growing Landscape of Endocrine and Biologic Treatments for Hormone Receptor-positive Breast Cancer

Conference Coverage

Learning Activities

Journals

A Comprehensive Review of the Growing Landscape of Endocrine and Biologic Treatments for Hormone Receptor-positive Breast Cancer

Keiichi Fujiwara, ESMO 2022: Clinical trial highlights in gynaecological cancer

ESGO 24: Advances in cervical, endometrial and ovarian cancer

Key insights in gynecological malignancies: BrUOG 354, AGO-OVAR 2.29/ENGOT-ov34, KEYVIBE-005, CARACO

Highlights in gynaecological oncology: Domenica Lorusso, ESMO 2023

Navigating HRT and cancer risk: PrEvCan | Celia Diez de los Rios

Cancer prevention and the power of breastfeeding: PrEvCan | Celia Diez de los Rios

Paul DiSilvestro, ESMO 2022: SOLO1/GOG-3004 trial - Olaparib for the treatment of advanced ovarian cancer - Overall survival findings at 7 years

Keiichi Fujiwara, ESMO 2022: Phase 3 GOTIC-002 LUFT study results - Chemotherapy with tegafur-uracil for locally advanced cervical cancer

Domenica Lorusso, ASCO 2022: Trabectedin for the treatment of recurrent ovarian, primary peritoneal, or fallopian tube cancers - Phase 3 MITO23 trial results

Ruth Perets, AACR 2022: Vibostolimab / Pembrolizumab Coformulation for the Treatment of Ovarian Cancer Naive to PD-1/PD-L1 Inhibitors

Domenica Lorusso, ESMO 2021: Relacorilant in Combination with Nab-paclitaxel for Patients with Recurrent Platinum-resistant Ovarian Cancer

Julius Strauss, ESMO 2021: Long-term Follow-up of Patients with HPV–associated Malignancies Treated with Bintrafusp Alfa

Shibani Nicum, ESMO 2021: First Results of the OCTOVA Trial

Linda Mileshkin, ESMO 2019 - Phase III OUTBACK trial in cervical cancer

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