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Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

Jorge Cortes, ASH 2022: New agents in relapsed or refractory acute myeloid leukaemia

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Published Online: Jan 5th 2023

Professor Jorge Cortes (Georgia Cancer Center, GA, USA) discusses his highlights from the recent ASH 2022 conference, including two new agents that look promising in early studies on patients with relapsed or refractory acute myeloid leukaemia.

Abstracts discussed:

Abstract 63: ‘The Menin Inhibitor SNDX-5613 (revumenib) Leads to Durable Responses in Patients (Pts) with KMT2A-Rearranged or NPM1 Mutant AML: Updated Results of a Phase (Ph) 1 Study‘ (00:10-02:20)

Abstract 64: ‘Update on a Phase 1/2 First-in-Human Study of the Menin-KMT2A (MLL) Inhibitor Ziftomenib (KO-539) in Patients with Relapsed or Refractory Acute Myeloid Leukemia‘ (02:20-03:46)

Disclosures: Jorge Cortes is a consultant for Novartis, Pfizer, Takeda, Sun Pharma and Rigel. He has received grant/research support from Novartis and Sun Pharma, and is on the advisory board for Novartis.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 64th ASH Annual Meeting & Exposition

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