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3D Rendered Medical Illustration of Male Anatomy - Colon Cancer; Ascending Colon.

Advances in Targeting KRAS G12C in Gastrointestinal Malignancies: Focus on KRAS G12C Inhibitors

Celine Hoyek, Angelo Pirozzi, Jeremy Jones

Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The RAS family consists of three major isoforms, namely the Harvey rat sarcoma virus (HRAS), the neuroblastoma RAS […]

touchREVIEWS in Oncology & Haematology. 2024;20(2):1–7:Online ahead of journal publication

Haematological Malignancies Leukaemia

5 mins

Jorge Cortes, ASH 2022: IDH1 inhibitors in the treatment of IDH1-mutant acute myeloid leukaemia – results from a phase II pivotal clinical trial

Published Online: Jan 5th 2023

Professor Jorge Cortes (Georgia Cancer Center, GA, USA) discusses the results from a recent clinical trial that were presented at ASH 2022. Abstract 2757: ‘Olutasidenib (FT-2102) Induces Durable Complete Remissions in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia. Results from a Planned Interim Analysis of a Phase 2 Pivotal Clinical Trial‘

Disclosures: Jorge Cortes is a consultant for Novartis, Pfizer, Takeda, Sun Pharma and Rigel. He has received grant/research support from Novartis and Sun Pharma, and is on the advisory board for Novartis.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 64th ASH Annual Meeting & Exposition

Access more Leukaemia content here

Focus on leukemia – Felix and ASC4FIRST

Elias Jabbour

The open-label, single-arm phase Ib/II Felix study (NCT04404660) investigated obecabtagene autoleucel (obe-cel, AUTO1), a novel anti-CD19 autologous CAR-T cell therapy, in adults with relapsed/refractory B-cell acute lymphoblastic leukemia. The results suggest that obe-cel can provide long-term remission without necessarily needing a transplant. touchONCOLOGY spoke with editorial board member, Elias Jabbour (MD Anderson Cancer Center, Houston, TX, USA), who summarized the key take-home messages from his presentation at ASCO 2024. Dr Jabbour also discussed the findings from the ASC4FIRST trial (NCT04971226).

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Advances in Targeting KRAS G12C in Gastrointestinal Malignancies: Focus on KRAS G12C Inhibitors

Conference Coverage

Learning Activities

Journals

Advances in Targeting KRAS G12C in Gastrointestinal Malignancies: Focus on KRAS G12C Inhibitors

Jorge Cortes, ASH 2022: IDH1 inhibitors in the treatment of IDH1-mutant acute myeloid leukaemia – results from a phase II pivotal clinical trial

Focus on leukemia – Felix and ASC4FIRST

Robin Foà, EHA 2023: José Carreras Award presentation - research on Philadelphia-positive acute lymphoblastic leukaemia

Robin Foà, EHA 2023: New developments in the treatment of Philadelphia-positive acute lymphoblastic leukaemia

Arnon Kater, EHA 2023: MURANO substudy analysis: Venetoclax-rituximab in patients with chronic lymphocytic leukaemia

Elias Jabbour, ASCO 2023: PhALLCON: A phase 3 study comparing ponatinib vs imatinib patients with Ph+ALL

Massimo Breccia, ASH 2022: Asciminib for patients with chronic myeloid leukaemia, the ASC4OPT study

Massimo Breccia, ASH 2022: The limitations of tyrosine kinase inhibitors in chronic myeloid leukaemia and approval status of asciminib

Jorge Cortes, ASH 2022: Advances in triplet therapy for relapsed or refractory acute myeloid leukaemia

Jorge Cortes, ASH 2022: New agents in relapsed or refractory acute myeloid leukaemia

John Mascarenhas, ASH 2022: Pacritinib for the treatment of myelofibrosis and severe thrombocytopenia, the PACIFICA study

John Mascarenhas, ASH 2022: Treatment challenges in myelofibrosis and severe thrombocytopenia and the rationale for the use of pacritinib

Jennifer Brown, ASH 2022: Zanubrutinib for patients with relapsed/refractory chronic lymphocytic leukaemia and small lymphocytic lymphoma, ALPINE (phase III) results

Mark Litzow, ASH 2022: Relapse rates, prognosis and blinatumomab approval status in patients with acute lymphoblastic leukaemia

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