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Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

Jorge Cortes, ASCO 2022: Week 96 update of the ASCEMBL trial of asciminib versus bosutinib in patients with CML-CP

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Published Online: Jul 18th 2022

Professor Jorge Cortes (Georgia Cancer Center, Augusta, GA, USA) shares the long-term efficacy and safety data from the 96-week update of the ASCEMBL trial of asciminib with a novel mechanism of action in patients with Philadelphia chromosome-positive chronic myeloid leukaemia chronic phase.

The abstract ‘Efficacy and safety results from ASCEMBL, a phase 3 study of asciminib versus bosutinib (BOS) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) after ≥2 prior tyrosine kinase inhibitors (TKIs): Week 96 update’ (Abstract 7004) was presented at the the 2022 American Society of Clinical Oncology (ASCO) annual meeting.

Disclosures: Jorge Cortes is consultant for, and has received grant/research support from Novartis, Pfizer, Takeda and Sun Pharma. He is also on the Advisory Board for Novartis and Pfizer.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 2022 American Society of Clinical Oncology (ASCO) annual meeting.

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