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Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential for minimal residual disease (MRD) detection and recurrence monitoring. In metastatic breast cancer (MBC), ctDNA […]

Yungan Tao, ESMO 2018 – Developments in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinomas

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Published Online: Nov 2nd 2018

In this interview at ESMO 2018, Dr Yungan Tao speaks about the GORTEC 2004-01 randomised phase III trial which looked at 70 Gy/35 F with conventional radiotherapy versus 75 Gy/35 F with intensity-modulated radiotherapy. Dr Tao explains the results and limitations of the study and how this information adds to the body of evidence to support the use of intensity-modulated radiotherapy for locally advanced head and neck squamous cell carcinomas.

Questions:
1. What is intensity-modulated radiotherapy (IMRT) and what are its advantages compared with conventional radiotherapy? (0:11)
2. What was the rationale for investigating dose escalation of radiotherapy when administered with cisplatin? (0:46)
3. What were the findings of this study? (1:26)
4. What were the limitations of this study? (2:53)
5. How do you expect the role of IMRT to evolve in the future? (3:43)

Speaker disclosures: Yungan Tao has nothing to disclose in relation to this interview.

Filmed at the European Society for Medical Oncology (ESMO) 2018 Congress, Munich, Germany, 19–23 October 2018.

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