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Inflammation of the breast in women. Female breasts with signs of the disease. A low-poly construction of interconnected lines and points. Blue background.
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Mohammad Ammad Ud Din, Hania Liaqat, Ayesha Tayyab

The incidence rate of breast cancer (BC) is the highest in Pakistan among all Asian countries.1 In 2018 alone, 2.1 million cases were diagnosed, although the exact number is likely much higher due to poor reporting in rural areas and the lack of a formal national cancer registry.1,2 Over the last decade, multiple non-governmental organizations and large […]

Alexander Perl, EHA 2019 – The Phase III ADMIRAL Trial

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Published Online: Jun 27th 2019

We are joined by Alexander Perl at EHA 2019 to discuss his presentation on gilteritinib significantly prolongs overall survival in patients with FLT3-mutated (FLT3MUT+) relapsed/refractory (R/R) acute myeloid leukemia (AML): results from the phase III ADMIRAL trial.

Questions
1. What are the major types of FLT3 mutation and what is their impact on prognosis? (0:05)
2. What are the major challenges in the treatment of FLT3-mutated acute myeloid leukemia (AML)? (1:05)
3. What are the advantages of gilteritinib compared to existing FLT3 inhibitors? (2:14)
4. Could you tell us a little about the ADMIRAL trial and its findings? (3:30)
5. What is the potential for using gilteritinib in the first-line treatment setting? (6:33)

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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