Trending Topic

4 mins

Trending Topic

Developed by Touch
Mark CompleteCompleted
BookmarkBookmarked

Bruton tyrosine kinase (BTK) plays a functional and integral role in B-cell receptor (BCR) signalling and is expressed in normal and malignant B cells. Given BTK’s central role in the survival and proliferation of malignant B cells, BTK inhibitors have been developed for use in various B-cell malignancies, with several US Food and Drug Administration approvals in […]

Alexander Perl, EHA 2019 – The Phase III ADMIRAL Trial

Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Published Online: Jun 27th 2019

We are joined by Alexander Perl at EHA 2019 to discuss his presentation on gilteritinib significantly prolongs overall survival in patients with FLT3-mutated (FLT3MUT+) relapsed/refractory (R/R) acute myeloid leukemia (AML): results from the phase III ADMIRAL trial.

Questions
1. What are the major types of FLT3 mutation and what is their impact on prognosis? (0:05)
2. What are the major challenges in the treatment of FLT3-mutated acute myeloid leukemia (AML)? (1:05)
3. What are the advantages of gilteritinib compared to existing FLT3 inhibitors? (2:14)
4. Could you tell us a little about the ADMIRAL trial and its findings? (3:30)
5. What is the potential for using gilteritinib in the first-line treatment setting? (6:33)

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

touchONCOLOGY.com is an independent information resource supporting physicians, clinicians and leading industry professionals in continuously developing their knowledge, effectiveness and productivity, via free-to-access content in multimedia formats.

Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Close Popup