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Bijal Shah, ASCO 2019 – Phase I results of ZUMA-3 trial

Published Online: June 10th 2019

ZUMA-3 investigator, Bijal Shah presents interim phase I data on KTE-X19 (NCT02614066). The need for this investigational anti-CD19 CAR T cell therapy in adult patients with relapsed/refractory acute lymphoblastic leukemia and its mechanism of action are discussed alongside the results of this study.

Questions

1. What are the major unmet needs in the treatment of adults with relapsed or refractory acute lymphoblastic leukaemia? (0:04)
2. Could you tell us a little about KTE-X19 and its mechanism of action? (1:08)
3. What were the key inclusion and exclusion criteria of the ZUMA-3 study? (1:58)
4. What were the efficacy and safety findings of the interim analysis of phase 1 of ZUMA-3? (3:08)
5. Please could you tell us how you managed neurotoxicity in this study? (3:54)

Speaker disclosure: Bijal Shah has acted as a consultant for Adaptive Biotechnologies, received honoraria from Pharmacyclics/Janssen and research funding from Incyte and Jazz Pharmaceuticals.

Filmed at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Chicago, IL, USA.

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