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Haematological Malignancies, Leukaemia

Othman Al-Sawaf, EHA, 2019 – Analysis of the CLL14 trial

Published Online: June 28th 2019

We are joined by Othman Al-Sawaf at EHA 2019 to discuss his presentation on high efficacy of venetoclax plus obinutuzumab in patients with complex karyotype (CKT) and chronic lymphocytic leukemia (CLL): A prospective analysis from the CLL14 trial.

Questions
1. Could you tell us a little about complex karyotype (CKT) in chronic lymphocytic leukemia (CLL) and its impact on prognosis? (0:05)
2. What are the limitations of current therapeutic options for CLL CKT patients? (1:13)
3. What is the rationale for the use of venetoclax plus obinutuzumab in this treatment setting? (2:00)
4. What were the efficacy and safety findings of your recent analysis of the CLL14 trial? (3:15)
5. Which patients are most likely to respond to this combination and in which patients is it contraindicated? (4:15)

Othman Al-Sawaf has no conflicts of interest to declare in relation to this video.

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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