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3d illustration of human body liver
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Allan A Lima Pereira, Gabriel Lenz, Tiago Biachi de Castria

Despite being considered a rare type of malignancy, constituting only 3% of all gastrointestinal cancers, the incidence of biliary tract cancers (BTCs) has been increasing worldwide in recent years, with about 20,000 new cases annually only in the USA.1–3 These cancers arise from the biliary epithelium of the small ducts in the periphery of the liver […]

Petra Langerbeins PhD, EHA 2019 – Results of the Phase III Double-blind Randomised CLL12 Trial

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Published Online: Jun 27th 2019

We are joined by Petra Langerbeins at the EHA annual meeting in Amsterdam to discuss her presentation on ibrutinib versus placebo in patients with asymptomatic, treatment-naive early-stage chronic lymphocytic leukaemia (CLL): primary endpoint results of the phase III double-blind randomised CLL12 trial.

Questions

1. What is the current treatment paradigm for patients with asymptomatic early-stage chronic lymphocytic leukaemia (CLL)? (0:05)
2. What are the limitations of available treatment options for people with asymptomatic high-risk CLL? (0:30)
3. Could you tell us a little about the findings of the phase III study of ibrutinib in this treatment setting? (1:06)
4. Which patients are most likely to respond to ibrutinib and in which is it contraindicated? (2:50)
5. What is the safety profile of ibrutinib and how can adverse events be managed? (3:55)

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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