Home > Petra Langerbeins PhD, EHA 2019 – Results of the Phase III Double-blind Randomised CLL12 Trial
Haematological Malignancies, Leukaemia

Petra Langerbeins PhD, EHA 2019 – Results of the Phase III Double-blind Randomised CLL12 Trial

Published Online: June 27th 2019

We are joined by Petra Langerbeins at the EHA annual meeting in Amsterdam to discuss her presentation on ibrutinib versus placebo in patients with asymptomatic, treatment-naive early-stage chronic lymphocytic leukaemia (CLL): primary endpoint results of the phase III double-blind randomised CLL12 trial.

Questions

1. What is the current treatment paradigm for patients with asymptomatic early-stage chronic lymphocytic leukaemia (CLL)? (0:05)
2. What are the limitations of available treatment options for people with asymptomatic high-risk CLL? (0:30)
3. Could you tell us a little about the findings of the phase III study of ibrutinib in this treatment setting? (1:06)
4. Which patients are most likely to respond to ibrutinib and in which is it contraindicated? (2:50)
5. What is the safety profile of ibrutinib and how can adverse events be managed? (3:55)

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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