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Allan A Lima Pereira, Gabriel Lenz, Tiago Biachi de Castria

Despite being considered a rare type of malignancy, constituting only 3% of all gastrointestinal cancers, the incidence of biliary tract cancers (BTCs) has been increasing worldwide in recent years, with about 20,000 new cases annually only in the USA.1–3 These cancers arise from the biliary epithelium of the small ducts in the periphery of the liver […]

Sabina Chiaretti, ASH 2019: Blinatumomab in Relapsed/Refractory Adult ALL

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Sabina Chiaretti, “Sapienza” University of Rome, discusses her presentation: Role of Blinatumomab in Minimal Residual Disease and Hematologic Relapsed/Refractory Adult Acute Lymphoblastic Leukemia Patients Treated over 5 Years. A Single Center Experience.

Questions

1. What are the limitations of current therapeutic options for patients with relapsed/refractory acute lymphoblastic leukemia (ALL)? (0:05)

2. What is the mechanism of action of blinatumomab? (0:54)

3. What were the major findings of your retrospective study? (1:46)

4. What did the study findings teach us about the safety profile of blinatumomab and how to manage toxicities? (2:58)

5. How are these findings likely to impact on clinical practice? (4:43)

 

Sabina Chiaretti has received consultancy fees from Amgen, Shire, Pfizer and incyte.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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