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Asrar A Alahmadi, Logan Roof, Claire Verschraegen

Highlights Immunotherapy, especially combinatory immunotherapy, has shown promise with prolonged survival for patients with advanced mesothelioma in the first-line setting (see the sections on ‘Systemic treatment and immunotherapy debut’ and ‘Randomized immunotherapy trials of mesothelioma’). Histology-based therapy is important to consider, with non-epithelioid subtypes responding better to immunotherapy than to chemotherapy (see the section on […]

Sabina Chiaretti, ASH 2019: Blinatumomab in Relapsed/Refractory Adult ALL

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Sabina Chiaretti, “Sapienza” University of Rome, discusses her presentation: Role of Blinatumomab in Minimal Residual Disease and Hematologic Relapsed/Refractory Adult Acute Lymphoblastic Leukemia Patients Treated over 5 Years. A Single Center Experience.

Questions

1. What are the limitations of current therapeutic options for patients with relapsed/refractory acute lymphoblastic leukemia (ALL)? (0:05)

2. What is the mechanism of action of blinatumomab? (0:54)

3. What were the major findings of your retrospective study? (1:46)

4. What did the study findings teach us about the safety profile of blinatumomab and how to manage toxicities? (2:58)

5. How are these findings likely to impact on clinical practice? (4:43)

 

Sabina Chiaretti has received consultancy fees from Amgen, Shire, Pfizer and incyte.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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