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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Shaji Kumar, ASH 2019: Advances in treatment approaches and guidelines for multiple myeloma

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Editor-in-Chief of Oncology & Hematology Review (US) Shaji Kumar (Mayo Clinic) discusses the latest advances in the treatment and guidelines of multiple myeloma.

Questions

1. What have been the most exciting recent development in the treatment of multiple myeloma? (0:05)

2. According to the most recent guidelines, what criteria are used to assess eligibility for autologous stem-cell transplant (ASCT)? (1:52)

3. What are the options for first-line therapy in transplant-ineligible patients? (3:38)

4. What factors influence the choice of first relapse therapy? (5:30)

5. How does risk status influence therapy in myeloma (newly diagnosed and relapse)? (6:36)

 

Shaji Kumar has no conflicts of interest to declare in relation to this video.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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