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Shaji Kumar, ASH 2020 – Highlights from ASH 2020

Published Online: January 7th 2021

It was a pleasure to speak with our Editor-in-Chief, Shaji Kumar (Mayo Clinic, Rochester, MN, USA) to discuss the use of MEDI2228 (Clinical Trial Identifier: NCT03489525) and anti-BCMA CAR-T cells (Clinical Trial Identifier: NCT03915184) in the treatment of patients with relapsed/refractory multiple myeloma and to find out his personal highlights from this year’s congress.

The abstracts ‘Phase 1, First-in-Human Study of MEDI2228, a BCMA-Targeted ADC in Patients with Relapsed/Refractory Multiple Myeloma‘ (ABSTRACT NUMBER: 179) and ‘Results from Lummicar-2: A Phase 1b/2 Study of Fully Human B-Cell Maturation Antigen-Specific CAR T Cells (CT053) in Patients with Relapsed and/or Refractory Multiple Myeloma‘ (ABSTRACT NUMBER: 133) were presented at the virtual 62nd ASH Annual Meeting and Exposition, 5-8 December, 2020.

Questions

  1. Please could you give an overview of MEDI2228 and its mechanism of action? (0:07)
  2. What have the findings of the first-in human study taught us about the efficacy and safety of MEDI2228 in patients with relapsed/refractory multiple myeloma? (1:08)
  3. What is the rationale for the use of anti-BCMA CAR-T cells in the treatment of patients with relapsed/refractory multiple myeloma? (3:33)
  4. On the basis of data from Lummicar-2, how does CT053 CAR-T cell therapy compare with other CAR-T cell therapies in development for multiple myeloma? (4:46)
  5. What were your personal highlights of this year’s ASH virtual congress? (6:53)

Speaker Disclosures: Research funding for clinical trials to the institution: Abbvie, Amgen, BMS, Carsgen, Janssen, KITE, Merck, Astra-Zeneca, Novartis, Roche-Genentech, Takeda, Tenebio; Consulting/Advisory Board participation: (with no personal payments) Abbvie, Amgen, BMS, Janssen, Roche-Genentech, Takeda, KITE, Astra-Zeneca, and (with personal payment) Oncopeptides, Beigene and Antagene.

Support: Interview and filming supported by Touch Medical Media Ltd.

Filmed in coverage of ASH 2020.

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