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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Benjamin A Weinberg, ASCO GI22: Pivotal Studies in Pancreatic Cancer

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Published Online: Mar 8th 2022

touchONCOLOGY were thrilled to speak to Professor Benjamin A Weinberg (Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA) to discuss the data from the TRYbeCA-1, KRYSTAL-1 and CISPD3 trials, which were presented at the ASCO Gastrointestinal Cancers Symposium 2022.

Questions

  1. What are the hopes of the new drug delivery mechanism using L-asparaginase to treat advanced pancreatic cancer? 00:15-01:13
  2. Why did the TRYbeCA-1 study fail to meet its primary endpoint? 01:13-02:53
  3. How have KRAS G12C inhibitors impacted clinical practice? 02:53-04:33
  4. What can you conclude from the updated results from the KRYSTAL-1 trial in KRAS G12C+ gastrointestinal cancers Cancers? 04:33-06:13
  5. How do you see the future for drug development in advanced pancreatic cancer? 06:14-08:19

Speaker Disclosure: Benjamin A Weinberg has no conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ASCO Gastrointestinal Cancers Symposium 2022.

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