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Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The RAS family consists of three major isoforms, namely the Harvey rat sarcoma virus (HRAS), the neuroblastoma RAS […]

Benjamin A Weinberg, ASCO GI22: Pivotal Studies in Pancreatic Cancer

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Published Online: Mar 8th 2022

touchONCOLOGY were thrilled to speak to Professor Benjamin A Weinberg (Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA) to discuss the data from the TRYbeCA-1, KRYSTAL-1 and CISPD3 trials, which were presented at the ASCO Gastrointestinal Cancers Symposium 2022.

Questions

  1. What are the hopes of the new drug delivery mechanism using L-asparaginase to treat advanced pancreatic cancer? 00:15-01:13
  2. Why did the TRYbeCA-1 study fail to meet its primary endpoint? 01:13-02:53
  3. How have KRAS G12C inhibitors impacted clinical practice? 02:53-04:33
  4. What can you conclude from the updated results from the KRYSTAL-1 trial in KRAS G12C+ gastrointestinal cancers Cancers? 04:33-06:13
  5. How do you see the future for drug development in advanced pancreatic cancer? 06:14-08:19

Speaker Disclosure: Benjamin A Weinberg has no conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ASCO Gastrointestinal Cancers Symposium 2022.

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