Julie Graff, ESMO 2019 – KEYNOTE-641 study in prostate cancer

We met with Julie Graff (Knight Cancer Institute) at ESMO 2019 to discuss unmet needs in the treatment of metastatic castration-resistant prostate cancer and KEYNOTE-641 (NCT03834493), a phase III study of pembrolizumab plus enzalutamide in this patient population.

Questions
1.     What are the current unmet needs in the treatment of metastatic castration-resistant prostate cancer (mCRPC) with androgen receptor inhibitors? (0:05)
2.     Could you tell us a little about the aims and design of the KEYNOTE-641 study? (0:50)
3.     What are the eligibility criteria for this study? (1:23)
4.     How can we overcome the challenge of identifying biomarkers predictive of response to pembrolizumab? (1:55)
5.     What other combined therapeutic approaches involving androgen receptor inhibitors are being investigated in the treatment of mCRPC? (2:51)

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

Speaker disclosure: Julie Graff has received travel expenses from Sanofi.

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