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Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

Axel Merseburger, ESMO 2019 – Advances in metastatic hormone-sensitive prostate cancer

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Published Online: Oct 8th 2019

Our Editor-in-Chief, Axel Merseberger (University Hospital Schleswig-Holstein), joined us at ESMO 2019 to discuss current limitations in the treatment of metastatic hormone-sensitive prostate cancer, use of antiandrogen agents, and what the future may hold.

Questions
1.   What are the limitations of the current standard of care for metastatic hormone-sensitive prostate cancer (mHSPC)? (0:05)
2.   What have recent clinical studies taught us about the optimum use of the antiandrogen agents enzalutamide, abiraterone acetate and apalutamide in the treatment of men with mHSPC? (0:40)
3.   What factors should be considered when making treatment decisions for mHSPC? (1:22)
4.   What is the safety profile of the anti-androgen agents? (2:02)
5.   What future role do you see for chemotherapy in the treatment of mHSPC? (2:52)
6.   What do you expect to be the next major breakthrough in the treatment of mHSPC? (3:49)

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

Speaker disclosure: Axel Merseberger has nothing to disclose in relation to this video.

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