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This issue of touchREVIEWS in Oncology & Haematology brings together a diverse collection of articles reflecting the growing complexity of cancer care and the continued evolution of precision medicine across tumour types. From rare malignancies and treatment-related challenges to emerging targeted therapies and novel biological insights, the contributions highlight both recent progress and the significant […]

Lung Cancer

An Introduction to Lung Cancer

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The five selected Plenary late-breaking abstracts at the ASCO 2026 Annual Meeting in Chicago showcased some of the meeting’s most practice-influencing data. Across prostate cancer, sarcoma, lung cancer and pancreatic cancer, these phase 3 studies demonstrated meaningful improvements in survival outcomes, highlighting the growing impact of perioperative intensification, precision oncology and novel targeted therapies in difficult-to-treat disease settings.

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This issue of touchREVIEWS in Oncology & Haematology brings together a diverse collection of articles reflecting the growing complexity of cancer care and the continued evolution of precision medicine across tumour types. From rare malignancies and treatment-related challenges to emerging ...

3d medical illustration of lung cancer
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Christopher R Pallas, Daniel R Carrizosa, Kathryn F Mileham

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide.1 Over the past two decades, the molecular characterization of NSCLC has transformed the therapeutic landscape by enabling the development of targeted therapies that have significantly improved outcomes ...

37 mins
CE/CME accredited
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touchEXPERT FOCUS
Prof. Marina Garassino, Prof. Jakob Nikolas Kather, Prof. Fernando Lopez-Rios

Three experts discuss how computational pathology can enhance diagnosis and treatment in NSCLC.

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See who the oncology community selected as the rising stars of 2026!

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As part of our touchONCOLOGY Future Leaders 2026 programme, Dr Federico Monaca reflects on the mentors who shaped his approach to research and clinical trials, the importance of patience and patient-centred care, and the transformative potential of next-generation immunotherapies.

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In this touchONCOLOGY Future Leaders 2026 interview, Dr Lenz reflects on the mentorship that shaped his commitment to oncology, the role of research in exposing inequities in cancer care, and why ensuring equitable access to innovation will define the future of the field.

37 mins
CE/CME accredited
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touchPANEL DISCUSSION
Dr Lyudmila Bazhenova, Dr Elvire Pons-Tostivint, Dr Julia Rotow

Expert faculty discuss antibody–drug conjugates (ADCs) in NSCLC with brain metastases, reviewing the clinical trial evidence, practical patient selection and sequencing alongside local CNS therapies, and the emerging pipeline of investigational ADCs.

93 mins
CE/CME accredited
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touchCLINICAL PERSPECTIVES
Prof. Pasi Jänne, Prof. Nicholas Girard, Dr Helena Yu, Prof. Paul Hofman

This three-part series covers managing advanced NSCLC after EGFR-TKI therapy, highlighting new treatments, biomarkers and MDT-based care.  

3 minutes
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Learn how RAS proteins play a crucial role in the regulation of cell proliferation and survival in normal cells. Oncogenic mutations in the RAS gene can drive cancer initiation and progression through disruption of this regulatory balance.

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2025 has brought exciting developments in oncology, with groundbreaking research and real-world progress showcased at ASCO, ESMO, EHA, ASH and many more leading conferences around the world. We asked our key faculty to share what they believe has been most impactful so far this year – here’s what they told us.

30 mins
CE/CME accredited
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touchTALKS
Dr Christine Bestvina

Targeting KRAS-mutated NSCLC: Dr Christine Bestvina shares expert insights on therapy advances

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Coverage from: ESMO 2025

The European Society for Medical Oncology (ESMO) 2025 congress brought over 100 late-breaking abstracts, 250 sessions, 600 expert speakers and 33,800 delegates to Berlin in October. The meeting highlighted innovations ranging from novel agents to real-world evidence and patient-centred care. In this article, hear from the experts on the key breakthroughs and clinical insights set to shape the future of oncology practice.

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Coverage from: ESMO 2025
Federico Monaca

At this year’s ESMO 2025 lung-cancer programme, several large phase II/III studies delivered practice-shaking results across EGFR-mutant, squamous, small-cell and ALK-positive disease. From upfront osimertinib plus chemo to antibody-drug conjugates in chemo-resistant EGFR-mutant disease and adjuvant ALK inhibition, here are the six landmark abstracts clinicians and researchers need to know — and what they could mean for the clinic.

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It is with great pleasure that we present the latest edition of touchREVIEWS in Oncology & Haematology. This edition showcases the continued advances and innovation reshaping cancer care, as well as highlighting the continued unmet needs and challenges associated with ...

Abstract Lungs with red human bronchial tree structure.
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Kübra Canaslan, Farheen Vhora, Fatemeh Ardeshir-Larijani

Early-onset lung cancer is typically defined as occurring in individuals aged 18–50 years, although there is no universally accepted definition.1–3 This entity, though rare, poses unique diagnostic and therapeutic challenges. This article synthesizes current evidence on the unique features and management ...

52 mins
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Watch in two short videos, leading thoracic oncologists share 2025 data on CheckMate 816 and CheckMate 77T.

3D Rendered Medical Illustration of The Lungs.
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At WCLC 2025, final FLAURA2 results revealed that osimertinib plus chemotherapy significantly improves overall survival in EGFR-mutant advanced non-small cell lung cancer (NSCLC), extending median survival to nearly four years. Experts stress the practice-changing impact, while highlighting the importance of tailoring treatment to patient fitness, comorbidities, and individual goals.

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