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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Arnaud Méjean, ASCO 2018 – Cytoreductive nephrectomy and the CARMENA trial

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Published Online: Jun 12th 2018

Arnaud Méjean from the HEGP, Université Paris Descartes and ADHP in Paris, France, discusses the place of cytoreductive nephrectomy in the management of patients with metastatic renal cell carcinoma, and how this approach may change based on the results of the CARMENA trial.

1. What is the current role of cytoreductive nephrectomy in the management of patients with metastatic renal cell carcinoma? (0:11)

2. How did the advent of targeted therapies affect the use of cytoreductive nephrectomy? (0:32)

3. Could you tell us a little about the design of the CARMENA clinical trial? (0:58)

4. What were the findings of this study? (2:02)

5. What patients are most likely to benefit from this approach? (3:08)

Speaker disclosures: Arnaud Méjean has nothing to disclose in relation to this video interview.

Filmed at the American Society of Clinical Oncology (ASCO) Annual Meeting 2018, Chicago, IL, US, June 1–5 2018

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