ONCOLOGY & HEMATOLOGY REVIEW (US) – VOLUME 8 ISSUE 2 – FALL 2012
Supportive Oncology
Anemia is defined by the World Health Organization as a hemoglobin (Hb) level
Over 1.6 million Americans will be diagnosed with cancer in 2012, adding to the approximately 12 million Americans already living with a diagnosis of cancer.1 The vast majority of these cancer patients are receiving or have completed treatment for their disease. The overall survival rate for all types of cancer has increased from less than […]
Prostate Cancer
Prostate cancer continues to be a leading cause of cancer-related death worldwide and is the most common malignancy among American men after skin cancer.1 Based on estimates by the American Cancer Society, approximately 241,740 new cases are expected to be diagnosed and 28,170 men are expected to die from the disease in the US in […]
Worldwide, prostate cancer is one of the most commonly diagnosed cancers in men. Approximately 900,000 new cases are reported each year with an estimated 242,000 cases in the US alone.1 Raised awareness leading to earlier detection and improved therapies have significantly extended life expectancy, as demonstrated by a decrease in US age-adjusted mortality of 3.7 […]
Melanoma
The incidence of melanoma is high and is the sixth most common cancer in US men and eighth most common cancer type in US women.1,2 Moreover, the incidence of metastatic melanoma has been increasing worldwide at a rate faster than any other solid malignancy.3 There were an estimated 76,250 new cases of melanoma and 9,180 […]
Hematological Malignancies
Multiple myeloma (MM) is a plasma cell malignancy characterized by the overproduction of monoclonal immunoglobulins and the presence of hypercalcemia, renal injury, anemia, osteolytic lesions, and frequent infections.1,2 Other complications include hyperviscosity and amyloidosis.1,2 It is the second most common hematologic malignancy after non-Hodgkin’s lymphoma and will represent nearly 15 % of new hematologic malignancies […]
F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used in the initial evaluation and response assessment of patients with Hodgkin’s lymphoma (HL). Its sensitivity for nodal and extranodal sites of disease can add to the staging information obtained with CT alone,1 and PET is valuable in the response assessment at […]
Adolescents and young adults (AYAs) are defined as those individuals between the ages of 15 and 39 years.1 AYAs with cancer are considered a vulnerable group, in large part due to psychosocial challenges in this population, including lack of insurance, low rates of clinical trial enrollment, issues pertaining to independence, and concerns about body image […]
Coagulopathy
Abstract Background: Hemorrhage continues to be a major cause of early death in trauma patients. Our understanding of the development of coagulopathy and its importance has evolved significantly over the last decade. In this article, we describe the current understanding of coagulopathy in the setting of trauma including its mechanisms, diagnosis, consequences, and treatment strategies. […]
Trending Topic
The first primary microangiopathic haemolytic anaemia was identified as thrombotic thrombocytopenic purpura (TTP) by Dr Moschowitz in 1924. At that time, the classic pentad of clinical features, still used today, included fever, erythrocyte fragmentation, thrombocytopenia, kidney injury and neurologic injury.1 It is now known that this disease is characterized by the deficiency of a disintegrin and metalloproteinase with thrombospondin-1-like […]
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