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Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential for minimal residual disease (MRD) detection and recurrence monitoring. In metastatic breast cancer (MBC), ctDNA […]

Paolo Ghia, EHA 2019 – ASCEND Phase III Study

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Published Online: Jul 14th 2019

We are joined by Paolo Ghia at EHA 2019 to discuss his presentation on ASCEND phase III study of acalabrutinib vs investigator’s choice of rituximab plus idelalisib (IDR) or bendamustine (BR) in patients with relapsed/refractory (R/R) chronic lymphocytic leukaemia (CLL). 

Questions

  1.   What are the current treatment options for relapsed/refractory CLL and what are their limitations? (0.05)
  2.   What is the rationale for the use of acalabrutinib in this treatment setting? (0.46)
  3.   Could you tell us a little about the ASCEND study? (1.21)
  4. What further studies are planned? (1.57)

Paolo Ghia has no conflicts of interest to declare in relation to this video.

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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