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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Abdulraheem Yacoub, ASH 2019: Novel Agents for the Treatment of PV and MF

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Abdulraheem Yacoub, University of Kansas Medical Center, discusses his presentation: MPN Tumor Board: Application of Novel Agents for the Treatment of Polycythemia Vera and Myelofibrosis.

Questions

1. What are the most exciting recent advances in the treatment of polycythemia vera and myelofibrosis? (0:05)

2. What role is next generation sequence technology likely to play in the future management of myeloproliferative neoplasms? (0:51)

3. How has increased understanding of these diseases helped select the most appropriate treatment strategy for an individual? (2:13)

4. What is the best treatment strategy for patients who experience symptomatic disease progression? (3:46)

5. What progress has been made in terms of combined therapy for the treatment of polycythemia vera and myelofibrosis? (6:30)

 

Abdulraheem Yacoub has been a consultant for Incyte, Novartis and Agios.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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