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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Louis Williams, ASH 2019: Genetic Segmentation and Targeted Therapeutics for Multiple Myeloma

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Louis Williams, NYU Langone Medical Center, provides a snapshot of his recent article with Oncology & Hematology (US) exploring genetic segmentation and targeted therapeutics for multiple myeloma.

Questions

1. How has increased understanding of the molecular biology of multiple myeloma impacted on risk stratification of patients? (0:05)

2. Could you tell us a little about B-cell maturation antigen targeted therapies? (1:02)

3. What other emerging targeted therapies seem promising? (2:34)

4. With so many new therapies available, how can we best incorporate them into the treatment paradigm? (3:56)

5. What other pathways are potential therapeutic targets? (5:28)

 

Louis Williams has no conflicts of interest to declare in relation to this video.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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