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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

TPO agents beyond ITP: aplastic anemia, inherited thrombocytopenia and chemotherapy induced thrombocytopenia

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Published Online: Feb 27th 2020

Speaker Prof. James Bussel

Learning objectives

– Understand that thrombopoietic agents (TPO) impacts the stem cell and thus can have trilineage effects

– Recognize that TPO agents are an important way to increase the platelet count in patients with inherited thrombocytopenia

– Evaluate the tole of TPO agents in chemotherapy-induced thrombocytopenia: which patients and which diseases

 

Published online: 27 February 2020

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