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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Srdan Verstovsek, ASH 2022: Momelotinib long-term safety in myelofibrosis disease – Analysis of SIMPLIFY-1, SIMPLIFY-2, and MOMENTUM trials

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Published Online: Jan 4th 2023

Momelotinib, an oral JAK1/JAK2/ACVR1 inhibitor, was evaluated in 3 randomised controlled trials – SIMPLIFY-1, SIMPLIFY-2, and MOMENTUM, in patients with high- and intermediate-risk myelofibrosis. In this touchONCOLOGY interview, we speak with Prof. Srdan Verstovsek (MD Anderson Cancer Center, Houston, TX, USA) to discuss the limitations of JAK inhibitor therapy in myelofibrosis, and the integrated analysis of momelotinib that characterized its long-term safety, with pooled data from the three trials, which represented a spectrum of myelofibrosis disease from early (JAK inhibitor-naive) to late (JAK inhibitor-experienced) stages.

The abstract entitled ‘Momelotinib (MMB) Long-Term Safety: Pooled Data from Three Phase 3 Randomized-Controlled Trials (RCTs)’ (Abstract #4348) was presented at 64th ASH Annual Meeting and Exposition, December 10-13 2022, New Orleans, LA, USA

  1. What are the current limitations of JAK inhibitor therapy in myelofibrosis, and how does the mechanism of action of momelotinib potentially overcome these limitations? (0:12)
  2. Could you give us a brief overview of the SIMPLIFY-1, SIMPLIFY-2, and MOMENTUM clinical trials in patients with high- and intermediate-risk myelofibrosis? (2:27)
  3. What do you see as the future of JAK inhibitors in myelofibrosis? (4:54)

Disclosures: Srdan Verstovsek has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of ASH 2022

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