Diagnosis and Management of Barrett’s Metaplasia

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Central Nervous System as a Sanctuary for Advanced Epidermal Growth Factor Receptor-mutant Non-small Cell Lung Cancer

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Lung cancer is the second most common type of cancer worldwide and in the USA, with its incidence varying depending on geographic and socioeconomic factors.1–3 According to data from the Global Cancer Observatory: Cancer Incidence, Mortality and Prevalence (GLOBACAN) database, an estimated 2.48 million new cases of lung cancer were reported in 2022.4,5 Although lung cancer rates in the […]

touchREVIEWS in Oncology & Haematology. 2025;21(1):Online ahead of journal publication

Gastrointestinal Cancers

< 1 min

Diagnosis and Management of Barrett’s Metaplasia

Benjamin Colleypriest

Published Online: Jun 15th 2012 European Gastroenterology & Hepatology Review, 2011;7(3):166–71

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Abstract

Overview

Barrett’s metaplasia (BM) is a common pre-malignant condition with unknown population prevalence, but an increasing endoscopic incidence. BM develops in the context of gastro-oesophageal reflux and is a major risk factor for oesophageal adenocarcinoma, which develops from BM via a metaplasia–dysplasia–carcinoma pathway. Current treatment strategies aim to prevent the progression through this pathway with drug regimes and detect dysplasia early via endoscopic surveillance. Multiple imaging modalities and adjuncts have been employed to detect dysplastic epithelium in BM, including high-definition endoscopy, confocal endomicroscopy, narrow band imaging, chromoendoscopy and autofluorescence. Historically, oesophagectomy was the only potentially curative treatment option for oesophageal adenocarcinoma in the context of BM, but the last 10 years have seen a dramatic increase in the use of endoscopic resection and ablation technologies. Endoscopic mucosal resection, photodynamic therapy and radiofrequency ablation can be considered for treatment of high-grade dysplasia and early oesophageal adenocarcinoma.

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Central Nervous System as a Sanctuary for Advanced Epidermal Growth Factor Receptor-mutant Non-small Cell Lung Cancer

Conference Coverage

Learning Activities

Journals

Central Nervous System as a Sanctuary for Advanced Epidermal Growth Factor Receptor-mutant Non-small Cell Lung Cancer

Diagnosis and Management of Barrett’s Metaplasia

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Overview

Article

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Durvalumab for the Treatment of Advanced Biliary Tract Cancer test

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