The mechanistic basis for non-small cell lung cancer (NSCLC) initiation in never smokers is unknown. The air pollutant, particulate matter, is known to be associated with the risk of NSCLC, however a direct cause and mechanism remains difficult to achieve. Prof. Charles Swanton (Francis Crick Institute, London, UK) joins touchONCOLOGY to discuss his study into how the mechanism of action and an actionable inflammatory axis for air pollution may induce NSCLC in never-smokers.
The abstract entitled ‘Mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: Towards molecular cancer prevention‘ Abstract 659MO, was presented at European Society for Medical Oncology (ESMO) 2022.
Questions:
- What is known about the cause of non-small cell lung cancer (NSCLC) in never smokers? (0:18)
- What were the aims, methodology and findings of your study? (1:00)
- What opportunities has this study presented for therapeutic development? (5:05)
Disclosures: Charles Swanton has nothing to disclose in relation to this video interview.
Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.
