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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Myung-Ju Ahn, WCLC 2021: Circulating Tumor DNA Assay as a predictor of clinical response in The AURA3 Trial

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Published Online: Oct 1st 2021

touchONCOLOGY joins Professor Myung-Ju Ahn (Samsung Medical Center, Seoul, South Korea) at WCLC 2021 to discuss the AURA3 trial of osimertinib as a treatment for EGFR-mutant non-small cell lung cancer.

Abstract: FP16.03
ClinicalTrials.gov Identifier: NCT02151981

Questions
1. What are the strengths and limitations of osimertinib as a treatment for EGFR-mutant non-small cell lung cancer? (00:17-01:13)
2. Could you give us a brief overview of the AURA3 clinical trial and its findings? (01:13-02:03)
3. What clinical evidence supports the use of circulating tumour DNA assay as a predictor of clinical response to osimetinib? (02:03-02:47)
4. Could you tell us a little about your analysis and its findings? (02:47-06:27)
5. What is the potential impact of these findings on clinical practice, and what further studies are needed? (06:27-07:45)

Disclosures: Myung-Ju Ahn has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 2021 WCLC Annual Meeting.

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