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Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

Myung-Ju Ahn, WCLC 2021: Circulating Tumor DNA Assay as a predictor of clinical response in The AURA3 Trial

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Published Online: Oct 1st 2021

touchONCOLOGY joins Professor Myung-Ju Ahn (Samsung Medical Center, Seoul, South Korea) at WCLC 2021 to discuss the AURA3 trial of osimertinib as a treatment for EGFR-mutant non-small cell lung cancer.

Abstract: FP16.03
ClinicalTrials.gov Identifier: NCT02151981

Questions
1. What are the strengths and limitations of osimertinib as a treatment for EGFR-mutant non-small cell lung cancer? (00:17-01:13)
2. Could you give us a brief overview of the AURA3 clinical trial and its findings? (01:13-02:03)
3. What clinical evidence supports the use of circulating tumour DNA assay as a predictor of clinical response to osimetinib? (02:03-02:47)
4. Could you tell us a little about your analysis and its findings? (02:47-06:27)
5. What is the potential impact of these findings on clinical practice, and what further studies are needed? (06:27-07:45)

Disclosures: Myung-Ju Ahn has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 2021 WCLC Annual Meeting.

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