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Bruton tyrosine kinase (BTK) plays a functional and integral role in B-cell receptor (BCR) signalling and is expressed in normal and malignant B cells. Given BTK’s central role in the survival and proliferation of malignant B cells, BTK inhibitors have been developed for use in various B-cell malignancies, with several US Food and Drug Administration approvals in […]

Niels Reinmuth, ESMO 2019 – Phase III MYSTIC trial in NSCLC

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Published Online: Oct 7th 2019

We are joined by Niels Reinmuth (Asklepios Kliniken Munich-Gauting) at ESMO 2019 to discuss his presentation on PD-L1 expression in primary tumours versus metastatic samples in the phase III MYSTIC study in first-line metastatic NSCLC.

Questions
1.   Could you tell us a little about the MYSTIC study and its major findings? (00:07)
2.   What was the relationship between programmed death-ligand 1 (PD-L1) expression and the efficacy of durvalumab? (00:50)
3.   How did the expression of PD-L1 differ between primary tumour and metastatic samples? (01:30)
4.    What are the implications of these findings for clinical practice? (01:51)

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

Speaker disclosure: Neils Reinmuth disclosed a relevant relationship with AstraZeneca.

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