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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Valsamo Anagnostou, WCLC 2021: A Biomarker-Directed, Multi-Center Phase II Study of Molecular Response Adaptive Immuno-Chemotherapy in Lung Cancer

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Published Online: Oct 1st 2021

touchONCOLOGY joins Dr Valsamo Anagnostou (Johns Hopkins University School of Medicine, Baltimore, MD, USA ) at WCLC 2021 to discuss her presentation on the circulating tumor DNA biomarker-directed blood test and immune checkpoint inhibitor therapy in people with advanced non-small cell lung cancer.

Clinical Trial Registry Identifiers: CRI-CCTG0002/BR.36, NCT04093167.

Questions
1. What are the major challenges of immune checkpoint inhibitor therapy in people with advanced non-small cell lung cancer? (00:10-01:36)
2. Could you tell us a little about the circulating tumor DNA biomarker-directed blood test, and the clinical evidence supporting its use? (01:36-03:39)
3. What were the aims, design and patient population of your phase II study? (03:39-05:55)
4. What are the primary outcome measures planned for this study? (05:55-06:45)
5. What future studies are planned? (06:45-08:18)

Disclosures: Valsamo Anagnostou receives research funding from Bristol Myers Squibb and AstraZeneca.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 2021 WCLC Annual Meeting.

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