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Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential for minimal residual disease (MRD) detection and recurrence monitoring. In metastatic breast cancer (MBC), ctDNA […]

Eva Domingo Domènech, EHA 2019 – The Phase II CHECKMATE 205 Study

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Published Online: Jun 26th 2019

We are joined by Eva Domingo Domènech at EHA 2019 to discuss her presentation on nivolumab plus doxorubicin, vinblastine and dacarbazine for newly diagnosed advanced-stage classical Hodgkin lymphoma: 2-year extended follow-up from cohort D of the phase II CHECKMATE 205 study.

Questions
1. What are the major unmet needs in the treatment of advanced stage classical Hodgkin lymphoma? (0:05)
2. What is the rationale for treatment with nivolumab followed by nivolumab plus doxorubicin, vinblastine and dacarbazine? (0:56)
3. Could you tell us about the efficacy and safety findings you are presenting from Cohort D of the CHECKMATE 205 study? (1:49)
4. Which patients are most likely to benefit from this treatment regimen and in which patients is it contraindicated? (3:00)
5. Can patients who receive nivolumab go on to receive allogeneic HSCT? (4:15)

Eva Domingo Domènech has no conflicts of interest in relation to this video.

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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