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Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential for minimal residual disease (MRD) detection and recurrence monitoring. In metastatic breast cancer (MBC), ctDNA […]

Martin Hutchings, EHA 2018 – ECHELON-1 trial and chemotherapy regimens in Hodgkin’s lymphoma

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Published Online: Jun 20th 2018

Martin Hutchings from Copenhagen University Hospital discusses the ECHELON-1 trial and treatment strategies in Hodgkin’s lymphoma.

1. What are the limitations of current ABVD chemotherapy regimes for advanced Hodgkin’s lymphoma? (0:10)

2. Could you tell us a little about the ECHELON-1 study and its findings? (1:04)

3. What toxicities were associated with the A+AVD regimen? (2:11)

4. What patients are most likely to respond to this approach? (4:46)

5. What future studies are planned? (6:05)

Speaker disclosures: Martin Hutchings has nothing to disclose in relation to this video interview.

Filmed at the 23rd Annual Congress of the European Association of Hematology (EHA), Stockholm, Sweden, June 14–17 2018

A+AVD = brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine; ABVD = doxorubicin, bleomycin, vinblastine, and dacarbazine

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