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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Annalisa Chiappella, EHA 2018 – TP53 Mutations in DLBCL: the FIL-DLCL04 Study

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Published Online: Jun 20th 2018

Annalisa Chiapella from Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino in Italy talks to touchONCOLOGY about patients with diffuse large B-cell lymphoma (DLBCL) with a TP53 mutation, and the aims and findings of the FIL-DLCL04 study to help tackle this.

1. Could you tell us a little about the FIL-DLCL04 study and its findings? (0:10)

2. What is the approximate percentage of patients with diffuse large B-cell lymphoma (DLBCL) with a TP53 mutation? (1:41)

3. What was the impact of TP53 mutations on the prognosis of these young patients with DLBCL? (3:03)

4. What treatment strategies are in clinical development for patients with DLBCL and a TP53 mutation? (4:01)

Speaker disclosures: Annalisa Chiappella has nothing to disclose in relation to this video interview.

Filmed at the 23rd Annual Congress of the European Association of Hematology (EHA), Stockholm, Sweden, June 14–17 2018.

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