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Multiple Myeloma
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Latest Developments in Cellular Therapy for Multiple Myeloma

Published Online: December 23rd 2020 Oncology & Hematology Review (US). 2020;16(2):Online ahead of journal publication
Authors: Tara K Gregory, Henning Schade, Jesús G Berdeja
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Article Information

Novel drugs and continuous therapy have improved outcomes in patients with multiple myeloma (MM), however current therapies are largely non-curative with diminishing durations of response with subsequent therapies. Cellular therapies including chimeric antigen receptor (CAR) T cells have started to illustrate deeper and longer durations of relapse in the relapsed/refractory (RR) population. Current research seeks to expand on the durability of response, novel combinations and targets as well as the timing of CAR T in the treatment schema. This review summaries the updates in cellular therapy for MM.


Multiple myeloma, chimeric antigen receptor T cells, BCMA


**This manuscript has been accepted for publication, but not yet copyedited or typeset, and may be subject to minor changes during the production process**

Article Information:

For all authors: Research Funding: all >10k
Tara K. Gregory’s institution receives research funds in her name from the following: Abbvie, Amgen, Acetylon, Bluebird, BMS, Celgene, Celularity, Constellation, CRISP Therapeutics, CURIS, EMD Sorono, Genentech, Glenmark, Janssen, Kesios, Lilly, Novartis, Poseida, Sanofi, Takeda, Teva, Vivolux

For Dr. Berdeja: Consultancy: all <10k
Institution received consultancy payments from the following: Amgen, BioClinica, BMS, Celgene, CRISPR Therapeutics, Janssen, Karyopharm, Kite Pharma, Legend, Prothena, SecuraBio, Servier, Takeda

Compliance With Ethics

This article involves a review of the MM CAR T cell therapy via a PUBMED literature review, recent presentations at medical conferences and ongoing research at ClinicalTrials.gov. It did not involve any studies with human or animal subjects performed by any of the authors.

Review Process

Double-blind peer review.


The named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.


Tara K Gregory, Sarah Cannon Research Institute, Denver, CO, USA.
E: tara.gregory@healthonecares.com


No funding was received in the publication of this article.

Open Access

This article is freely accessible at touchONCOLOGY.com © Touch Medical Media 2020.



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