Bronchoscopy is the most important tool in diagnosing respiratory disorders. Diagnostic indications are numerous and range from bronchial wash or bronchoalveolar lavage, in case of pulmonary infiltrations, to transbronchial lung biopsies in peripheral solitary pulmonary nodules. Different techniques, such as peripheral endobronchial ultrasound probes, or different navigation systems facilitate diagnosis of peripheral pulmonary lesions. Furthermore, endobronchial-guided transbronchial needle aspiration gained increased significance for mediastinal staging in lung cancer patients. Bronchoscopy also offers many therapeutic modalities. In case of haemoptysis, cold saline lavage, instillation of topical vasoconstrictive agents, endobronchial airway blockade, laser therapy, argon plasma coagulation and electrocautery present useful tools. Another indication for therapeutic bronchoscopy is a central airway obstruction resulting from benign or malignant processes. Rapid symptom control can be achieved by laser-assisted resection, electrocautery and cryodebridement. Furthermore, the insertion of an airway stent re-establishes the patency of obstructed airways. Brachytherapy is another treatment option for malignant airway stenoses. Due to its delayed effects, brachytherapy should only be considered in respiratorily stable patients. Recently developed therapeutic modalities are endoscopic lung volume reduction in patients with chronic obstructive pulmonary disease and bronchial thermoplasty in patients with asthma.
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Welcome to the latest issue of touchREVIEWS in Oncology & Haematology. We are honoured to present a series of compelling articles that reflect cutting-edge developments and diverse perspectives in this ever-evolving field. This issue includes a series of editorials and reviews from esteemed experts who provide insights into novel therapies and their potential to change […]
Unmet clinical needs for patients with advanced epidermal growth factor receptor-mutated non–small-cell lung cancer Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have become the standard first-line therapy for patients with advanced non–small-cell lung cancer (NSCLC) harbouring ...
Accurately detecting lung tumours and their margins is important for disease outcomes.1,2 However, detection is challenging due to the use of minimally invasive surgery and current localization techniques, such as computed tomography (CT)-guided and endobronchial interventions, which add significantly ...
Cancer treatment has expanded rapidly in recent years as advancements in the fields of tumour biology and molecular diagnostics have informed the development of targeted therapies, improving survival in patients with oncogene-addicted cancers with therapeutically relevant molecular lesions. Osimertinib has ...
The treatment of patients with non-small cell lung cancer (NSCLC) has seen significant advances in the past decade, with the availability of multiple targeted therapy agents for oncogenic-driven non-squamous NSCLC and the advent of immunotherapy that has completely revolutionized the ...
Advanced non-small cell lung carcinoma (NSCLC) treatment paradigms have evolved during the past decade. Identification of tumor-specific molecular alteration in cancer driver genes has led to the development of targeted therapies.1–3 Most of the tumors harboring such alterations are sensitive ...
Radiation-induced esophagitis, caused by incidental damage to the mucosal lining of the esophagus during radiation therapy, is a common and clinically important toxicity in patients with lung cancer. Esophagitis generally develops 2–3 weeks after initiation of radiation therapy and presents as ...
Historically, chemotherapy represented the only available treatment for patients with advanced non-small-cell lung cancer (NSCLC) who did not show any target molecular driver, such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) or the receptor tyrosine kinase ROS1. ...
At initial diagnosis of metastatic disease, central nervous system (CNS) metastases are present in 22–33% of patients with anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC). After crizotinib failure, the incidence can reach up to 70%, compared with 40% in ...
Non-small cell lung cancer (NSCLC) remains a world-wide health issue, accounting for 85% of all lung cancers, of which there were an estimated 2.1 million new cases and 1.76 million deaths in 2018; equivalent to 11.6% of the global cancer burden.1,2Â This incidence is expected ...
Welcome to the fall edition of Oncology and Hematology Review (US), which features a wide variety of articles covering topics of interest to oncologists and hematologists, as well as the wider medical community. We begin with some expert interviews, which ...
Lung cancer is the leading cause of cancer deaths in the USA. In 2018 an estimated 154,050 Americans were predicted to die from lung cancer, accounting for approximately 25% of all cancer deaths.1 However, recent advances have transformed early diagnosis and the treatment ...
Small cell lung cancer (SCLC) is an aggressive high-grade bronchogenic carcinoma with neuroendocrine features occurring predominantly in current or former smokers.1 Despite initial sensitivity to platinum-based chemotherapy, almost all patients will relapse and develop resistance to conventional treatment.2 At present, ...
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