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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Michael Atkins: Safe and Effective Use of Immune Checkpoint Inhibitors in Patients with Cancer

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Published Online: Feb 21st 2022

Dr Michael Atkins (MedStar Georgetown University Hospital, Washington, DC, USA) shares three areas for development to help improve the safe and effective use of immune checkpoint inhibitors.

1. Having a rational approach to stopping therapy (00:50-02:20)
2. An improved understanding of toxicity and response (02:20-04:25)
3. The role of combining and sequencing immunotherapy with standard treatment (04:30-06:05)

Speaker Disclosure: Michael Atkins is a member of the advisory board at: BMS, Merck, Novartis, Eisai, Aveo, Pfizer, Werewolf, Fathom, Pneuma, Leads, Pyxis Oncology, PACT, Elpis, X4Pharma, ValoHealth, ScholarRock, Surface, Takeda, Simcha, Roche and SAB Bio. He has been a consultant for: BMS, Merck, Novartis, Pfizer, Roche, Exelixis, Iovance, COTA, Idera, Agenus, Apexigen, Asher Bio, Neoleukin, AstraZeneca, Calithera, SeaGen and Sanofi. He has received research support to his institution from BMS, Merck, Pfizer, and has stock options at Werewolf, Pyxis Oncology and Elpis.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

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